Ibutamoren (Mk-677)
(3rd Party Tested in USA) (batch 3/22/2022) click here
Summary of Benefits of Ibutamoren:
1) It Helps build muscles and increases bone density
2) It Improves Sleep
3) It has bee used in clinical trials for hGH Deficiency
4) It might help in wound healing and tissue regeneration
Where to buy mk 677 :
Growth hormone problem:
Human growth hormone (hGH) is a hormone that interact with most tissues in human body, a shortage in hGH in early stages may cause decreased muscle mass, increased fat mass and undesirable of alteration in blood lipid concentration [1]. The injection of hGH has serious side effects such as carpal tunnel syndrome, so that secretagogues was suggested [4]. The treatment for this problem is to use hGH itself (a peptide with 191 amino acids) by controlling the hGH secretion. The growth hormone releasing hormone (GHRH) and somatostatin (SRIF) are two hormones that are known to control the release of hGH [2]. In 1984, Momany and others introduced a small peptides called GHSs that has a distinct mechanism other than GHRH and SRIF [3].
Ibutamoren (MK-677):
MK-677 is known as L-163,191 in different scientific articles [4] [5]. In 1995, A group of research at Merck discovered a receptor to which MK-677 binds. Ibutamoren MK 677 is a derivatized dipeptide which is used in clinical trial as oral active GHS. The reason that GHS is consider the best oral active drug among others: GHRH, SRIF, and hHG is its low molecular weight [4].
The scientific benefits of MK-677:
The results show that MK-0751 increases the secretion of GH in young male volunteers [5]. The results show that MK-677 increases the level of GH in dogs after oral doses as low as o.125 mg/kg. The Figure below shows that when a dosage of MK-677 (L-163, 191) increases from 0.01 mg/kg to 0.1 mg/kg the associated mean serum GH from 5 to 35 ng/ml during the peak value [4]. In addition, Ibutamoren MK 677 does not cause any water retentions.
Side effects of MK-677:
The results showed that the release of GH using MK-677 does not significantly affect the plasma level of aldosterone, prolactin, luteinizing hormone, and thyroxine after oral administration of 1mg/kg [4]. The results showed an increase in cortisol. Thus, the MK-677 was selected for clinical studies. However, it is not approved by the FDA for human consumption.
Where to buy MK 677 with highest quality ?
[1] Salomon F, Cuneo R, Sönksen PH. Growth hormone and protein metabolism. Hormones. 1991;36(Suppl. 1):41-3.
[2] Merimee TJ, Laron Z, LeRoith D. Growth hormone, IGF-I and growth: new view of old concepts. Freund; 1996.
[3] Momany FA, Bowers CY, Reynolds GA, Hong A, Newlander K. Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides. Endocrinology. 1984 May 1;114(5):1531-6.
[4] Patchett AA, Nargund RP, Tata JR, Chen MH, Barakat KJ, Johnston DB, Cheng K, Chan WW, Butler B, Hickey G. Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proceedings of the National Academy of Sciences. 1995 Jul 18;92(15):7001-5.
[5] Gertz BJ, Barrett JS, Eisenhandler R, Krupa DA, Wittreich JM, Seibold JR, Schneider SH. Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6. The Journal of Clinical Endocrinology & Metabolism. 1993 Nov 1;77(5):1393-7.
[6] Copinschi GE, Van Onderbergen AN, L'Hermite-Balériaux M, Mendel CM, Caufriez A, Leproult R, Bolognese JA, De Smet M, Thorner MO, Van Cauter E. Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men. The Journal of Clinical Endocrinology & Metabolism. 1996 Aug 1;81(8):2776-82.